Dr. Sharmila Anishetty

Areas of specialization

• Protein Structure Studies

• Systems Biology

• Molecular Dynamics simulations of Enzymes

• Comparative Genomics

Research Guidance

No. of students completed Ph.D : 9

No. of students completed M.S. by Research : 2

Guided several B.Tech and M.Tech projects

Publications

• David P Annaraj, Priyadarsini Kadirvel, Ahalyaa Subramanian, Sharmila Anishetty. "Free enzyme dynamics of CmaA3 and CmaA2 cyclopropane mycolic acid synthases from Mycobacterium tuberculosis: Insights into residues with potential significance in cyclopropanation".J Mol Graph Model (2019) 91:61-71.
• Ahalyaa Subramanian, Priyadarsini Kadirvel, Sharmila Anishetty. "Insights into the pH-dependent catalytic mechanism of Sulfolobus solfataricus β-glycosidase: A molecular dynamics study". Carbohydrate Research. (2019) 480:42-53.
• Sundaresan L, Kumar P, Manivannan J, Balaguru UM, Kasiviswanathan D, Veeriah V, Anishetty S, Chatterjee S. "Thalidomide and Its Analogs Differentially Target Fibroblast Growth Factor Receptors: Thalidomide Suppresses FGFR Gene Expression while Pomalidomide Dampens FGFR2 Activity". Chem Res Toxicol. (2019) 32(4):589-602.
• Priyadarsini Kadirvel, and Sharmila Anishetty. "Potential role of Salt-Bridges in the hinge-like movement of Apicomplexa specific β‐hairpin of Plasmodium and Toxoplasma profilins: A Molecular Dynamics Simulation Study." Journal of cellular biochemistry (2018) 119:3683-3696.
• Sherlin Durairaj, and Sharmila Anishetty. "A pipeline for proteome-scale identification and studies on hormone sensitive lipases in Mycobacterium tuberculosis." Computational biology and chemistry 71 (2017): 201-206.
• Maziya Ibrahim, Ahalyaa Subramanian, and Sharmila Anishetty. Comparative pan genome analysis of oral Prevotella species implicated in periodontitis. Functional & Integrative Genomics 17, (2017): 513.
• Shobana Sundar, David Annaraj, Anitha Selvan, Pallavi Guha Biswas, Reshma Vijayakumaran and Sharmila Anishetty. Functional insights from a comparative study on the dynamics of Antigen85 proteins and MPT51 from Mycobacterium tuberculosis. Journal of molecular modelling 21, 12 (2015): 310.
• Anitha Selvan, and Sharmila Anishetty. Cavities create a potential back door in epoxide hydrolase Rv1938 from Mycobacterium tuberculosis—A molecular dynamics simulation study. Computational biology and chemistry 58 (2015): 222-230.
• Sherlin Durairaj, and Sharmila Anishetty. Mechanistic insights from molecular dynamic simulation of Rv0045c esterase in Mycobacterium tuberculosis. Journal of molecular modeling 21, no. 4 (2015): 1-8.
• Singaravelu Muthukumar, Anitha Selvan, and Sharmila Anishetty. Molecular dynamics simulations of lectin domain of FimH and immunoinformatics for the design of potential vaccine candidates. Computational biology and chemistry 52 (2014): 18-24.
• Singaravelu Muthukumar, Kirubagaran Ramalingam, and Sharmila Anishetty. In silico analysis of adhesive foot proteins of mussels. INDIAN J. MAR. SCI43, no. 11 (2014).
• Jayakumar J, Anishetty S. Molecular Dynamics simulations of Inhibitor of Apoptosis Proteins and identification of potential small molecule inhibitors. Bioorg Med Chem Lett. 2014 May 1;24(9):2098-104.
• Murahari P, Anishetty S, Pennathur G. Understanding the lid movements of LolA in Escherichia coli using molecular dynamics simulation and in silico point mutation. Comput Biol Chem. 2013 Dec;47:71-80.
• BinnyPriya S, Saha S, Anishetty R, Anishetty S. A matrix based algorithm for Protein-Protein Interaction prediction using Domain-Domain Associations. J Theor Biol. 2013 Jun 7;326:36-42.
• Ibrahim M, Anishetty S. A meta-metabolome network of carbohydrate metabolism: interactions between gut microbiota and host. BiochemBiophys Res Commun. 2012 Nov 16;428(2):278-84.
• Selvaraj S, Sambandam V, Sardar D, Anishetty S. In silico analysis of DosR regulon proteins of Mycobacterium tuberculosis. Gene. 2012 Sep 10;506(1):233-41.
• Selvan A, Seniya C, Chandrasekaran SN, Siddharth N, Anishetty S, Pennathur G. Molecular dynamics simulations of human and dog gastric lipases: insights into domain movements. FEBS Lett. 2010 Nov 19;584(22):4599-605.
• Mohan, Abhilash, Sharmila Anishetty, and Pennathur Gautam. Global metal-ion binding protein fingerprint: A method to identify motif-less metal-ion binding proteins. Journal of Bioinformatics and Computational Biology 8.04 (2010): 717-726.
• Krishna V, Kumar KS, Anishetty S, Pennathur G. Investigations on domain movements of N-acetyltransferase in nano scale. J NanosciNanotechnol. 2009 Sep;9(9):5493-6.
• Majumder S, Rajaram M, Muley A, Reddy HS, Tamilarasan KP, Kolluru GK, Sinha S,Siamwala JH, Gupta R, Ilavarasan R, Venkataraman S, Sivakumar KC, Anishetty S,Kumar PG, Chatterjee S. Thalidomide attenuates nitric oxide-driven angiogenesis by interacting with soluble guanylyl cyclase. Br J Pharmacol. 2009 Dec;158(7):1720-34.
• Kaushik Ramakrishnan S, Vinatha Krishna, Vinod kumar KS, Lakshmi BS, Sharmila Anishetty, GautamPennathur. Molecular dynamics simulations of lipases. (2008) International Journal of Integrative Biology, 2(3): 204-213.
• Kadalmani K, Deepa S, Bagavathi S, Anishetty S, Thangaraj K, Gajalakshmi P. Independent origin of 185delAG BRCA1 mutation in an Indian family. Neoplasma. 2007;54(1):51-6.
• Thilakaraj R, Raghunathan K, Anishetty S, Pennathur G. In silico identification of putative metal binding motifs. Bioinformatics. 2007 Feb 1;23(3):267-71.
• Anishetty S, Pennathur G. Distribution of tripeptides in MHC binding peptides. Protein Pept Lett. 2007;14(6):552-6.
• Anishetty S, Anishetty R, Pennathur G. Understanding mutations and protein stability through tripeptides. FEBS Lett. 2006 Apr 3;580(8):2071-80.
• Anishetty S, Pulimi M, Pennathur G. Potential drug targets in Mycobacterium tuberculosis through metabolic pathway analysis. ComputBiol Chem. 2005 Oct;29(5):368-78.
• Cherukuvada SL, Seshasayee AS, Raghunathan K, Anishetty S, Pennathur G. Evidence of a double-lid movement in Pseudomonas aeruginosa lipase: insights from molecular dynamics simulations. PLoSComput Biol. 2005 Aug;1(3):e28.
• Santhiya ST, Manisastry SM, Rawlley D, Malathi R, Anishetty S, Gopinath PM, Vijayalakshmi P, Namperumalsamy P, Adamski J, Graw J. Mutation analysis of congenital cataracts in Indian families: identification of SNPS and a new causative allele in CRYBB2 gene. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3599-607.
• Giri AV, Anishetty S, Gautam P. Functionally specified protein signatures distinctive for each of the different blue copper proteins. BMC Bioinformatics. 2004 Sep 9;5:127.
• Anishetty S, Pennathur G, Anishetty R. Tripeptide analysis of protein structures. BMC Struct Biol. 2002 Dec 21;2:9.

Honors and Awards

• University First Rank in M.Sc. Biochemistry

• TATA Certified faculty in UNIX, C and Oracle.

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