Jaisy Samuel

Past Research Experience

• Under the supervision of Dr. Mahaboob Khan Rasool, I had evaluated the hepatoprotective and antioxidant effects of Spirulina fusiformis (a cyanobacterium family Oscillatoriaceae) against acetaminophen induced hepatotoxicity in mice. This study demonstrated that acetaminophen increases serum TNF-α and Spirulina fusiformis treatment reduced significantly reduced the elevated TNF-α level in acetaminophen challenged mice.

• I had also evaluated the hepatoprotective effect of gallic acid (3,4,5-trihydroxybenzoic acid), a plant phenol in acetaminophen induced hepatotoxic mice and our findings reveal that gallic acidtreatment alleviates the progression of the inflammation mediator TNF-a in paracetamol-exposed mice.

• Under the supervision of Dr.JuttaPapenbrock, I had studied the homologous and heterologous expression of arabidopsissulphotransferase and D-Cysteine desulphhydrase proteins.

• Under the supervision of Prof.JagatKanwar and Dr. Rupinder Kanwar, I had studied the effects of bovine lactoferrin and survivin dominant negative mutant on Retinoblastoma cells.

A Brief Summary Of The Research Project And Contribution In Vision Research Foundation, Sankara Nethralaya

At Vision Research Foundation, SankaraNethralaya, Chennai, I was a key researcher in the area of “Retinoblastoma & Therapy” at the laboratory for Ocular Pathology. In the field of retinoblastoma my major focus was targeted radioiodine therapy to cancer cells to improve the impact of radionuclide therapy on cancer cells alone. My research has direct relevance in therapy of cancers.

Publications

• EvanPrince Sabina, Jaisy Samuel, SeguRajappaRamya, Smita Patel, NiharikaMandal, PreetyPranatharthiiharan, PunyaPallabi Mishra, MahaboobKhanRasool(2009) Hepatoprotective and antioxidant potential of Spirulina fusiformis on acetaminophen- induced hepatotoxicity in mice. International Journal of Integrative Biology. 2009 Feb(6):1-5.
• MahaboobKhanRasool, EvanPrince Sabina, SeguRajappaRamya, PreetyPranatharthiiharan, Smita Patel, NiharikaMandal, , PunyaPallabi Mishra,Jaisy Samuel; Hepatoprotective and antioxidant effects of gallic acid in paracetamol- induced liver damage in mice; Journal of Pharmacy and Pharmacology; 2010 May;62(5):638-43.
• Upregulation of sodium iodide symporter (NIS) protein expression by an innate immunity component: Promising potential for targeting radiosensitive retinoblastoma; Jaisy Samuel, Narinderbir Singh, JagatRakeshKanwar, SubramaniumKrishnakumar, RupinderKaur Kanwar; Experimental Eye Research; 2015; 139; 108-114.
• A Study of Gene Expression of Survivin, its Antiapoptotic Variants, and Targeting Survivin In Vitro for Therapy in Retinoblastoma. Samuel, Jaisy MSc; Kanwar, Rupinder K. PhD; Kanwar, Jagat R. PhD; Khetan, Vikas MD; Krishnakumar, Subramanian MD; Journal of Pediatric Hematology/Oncology.2016 Oct;38(7):e230-42

Posters (International)

• Second prize in poster presentation for “SODIUM IODIDE SYMPORTER IN RETINOBLASTOMA” in DIRI Symposium, Frontiers in Science-21-23 Nov.-2011, Deakin University, Australia, in association with TERI, Delhi.
• Poster presentation on the topic “TARGETED GENE DELIVERY USING PEI IN EpCAM POSITIVE CELLS BY EpCAM APTAMER” in DIRI Symposium, Frontiers in Science-21-23 Nov.-2011, Deakin University, Australia, in association with TERI, Delhi.

Paper (International)

• Paper presentation onSODIUM IODIDE SYMPORTER IS DIFFERENTIALLY EXPRESSED IN RETINOBLASTOMA AND CORRELATES WITH THE AGGRESSIVENESS OF TUMORSin Meeting of the International Society for Genetic Eye Diseases & Retinoblastoma (ISGEDR) Ghent, Belgium, August 22 – 24, 2013.

Other Relevant Information

• Actively participated and harmonized the mammalian cell culture laboratories in the Department of Nano biotechnology at Vision Research Foundation, SankaraNethralaya, Chennai, India.
• Handled the responsibilities as a Senior Research Fellow in a BARC/BRNS sponsored project (BRNS/35/17/2009) of grant Rs.28 lakhs.
• In collaboration with Board of Research in Nuclear Sciences, Mumbai, I had worked with radioactive substances under the supervision of Dr.Archana Mukherjee.
• I also had opportunity to work with Prof. Juttapapenbrock and group at INSTITUT FÜR BOTANIK, LEIBNIZ UNIVERSITÄT, GERMANY.

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